Rejuran vs Profhilo: Which Skin Booster Is Right for You?

If you have spent any time researching skin boosters in Malaysia, you have probably bumped into two names again and again: Rejuran and Profhilo. Both are top tier injectables. Both have rave reviews. Both are loved by Malaysian patients who want better skin without going under the knife. So which one should you actually pick?

Here is the honest answer up front: neither is better than the other. They do completely different jobs. Rejuran heals your skin from within. Profhilo deeply hydrates and remodels it. Choosing between them is less about which is “better” and more about what your skin actually needs right now.

This guide breaks down both treatments side by side, explains the real difference in plain English, and helps you figure out which one (or which combination) fits your skin best.

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Rejuran vs Profhilo at a Glance

Here is the quick comparison. Use this table for a fast answer, then read the sections below for a clearer picture of what each treatment actually does.

Feature	Rejuran	Profhilo
Main ingredient	Polynucleotides (PDRN, salmon DNA)	Pure hyaluronic acid (high concentration)
Best for	Repair, acne scars, sensitive skin	Hydration, firmness, early skin laxity
How it works	Heals skin from within, stimulates regeneration	Bio remodels skin, deep hydration and lift
Sessions needed	3 to 4 sessions, 2 to 4 weeks apart	2 sessions, 4 weeks apart
Results visible	Gradual, over 2 to 3 months	Faster, within 1 to 2 weeks
Results last	6 to 12 months	6 to 9 months
Downtime	Tiny bumps for 1 to 2 days	Mild redness for 1 to 2 days

What Is Rejuran?

Rejuran is a Korean injectable made from polynucleotides (PN) derived from highly purified salmon DNA. Often nicknamed the “baby skin injection,” Rejuran is famous for its healing and regenerative properties. Rather than just hydrating the skin, it actually triggers your skin to repair and rebuild itself from within. Read more on our Rejuran Treatment Malaysia page.

It comes in 4 variants (Healer, I, S, and HB), each designed for a different concern. Rejuran S, for example, is specifically formulated for acne scars, while Rejuran I targets the delicate under eye area. This variant flexibility is part of what makes Rejuran so versatile.

What Is Profhilo?

Profhilo is an Italian injectable made of ultra pure hyaluronic acid in one of the highest concentrations on the market. It uses a clever technique called BAP (Bio Aesthetic Points), where it is injected at just 5 strategic points on each side of the face. From there, it spreads evenly under the skin, delivering deep hydration and stimulating collagen and elastin. Learn more on our Profhilo Treatment Malaysia page.

Unlike traditional fillers, Profhilo does not add volume. Instead, it improves the overall quality, firmness, and bounce of the skin, especially for areas where early laxity tends to show up first like the face, neck, and hands.

The Core Difference: Repair vs Remodel

Most articles list out ingredients and session counts but never actually explain why these two treatments feel so different. Here it is in plain English.

Rejuran heals. Its polynucleotides mimic your skin’s natural DNA fragments, signalling your cells to repair damage, calm inflammation, and regenerate. Think of it as deep tissue therapy for your skin. It is especially powerful for skin that has been through something difficult: acne breakouts, sun damage, sensitivity, or scarring.

Profhilo remodels. Its concentrated hyaluronic acid spreads through the deeper layers, flooding your skin with moisture and triggering new collagen and elastin production. Think of it as rebuilding the scaffolding of your skin so it sits firmer, plumper, and bouncier on the surface.

Different jobs. Different results. The right choice depends on what your skin is asking for right now.

Which One Is Right for You?

Rather than choosing based on which treatment sounds fancier, choose based on your specific concern. Here is how our doctors at Five Clinic® usually match patients to either Rejuran or Profhilo.

Best for acne scars and depressed scars: Rejuran — Especially Rejuran S, which has a higher concentration designed for scar repair. Often combined with Pico Laser for best results.

Best for early skin laxity and loss of bounce: Profhilo — The BAP technique lifts and remodels skin in a way Rejuran does not. Ideal for jowls, neck lines, and crepey hands.

Best for sensitive or reactive skin: Rejuran — Polynucleotides have anti inflammatory properties that calm and strengthen the skin barrier.

Best for dehydrated, dull skin: Profhilo — Its high concentration of hyaluronic acid delivers visible hydration and glow within 1 to 2 weeks.

Best for fine lines around the eyes: Rejuran — Rejuran I is specifically formulated for the delicate under eye area, smoothing crepey skin and softening dark circle shadows.

Best for neck and hands: Profhilo — One of the few skin boosters with strong clinical evidence for treating the neck and hands, where signs of aging often show first.

Best for post laser or post procedure recovery: Rejuran — Its healing properties make it ideal for repairing skin that has just been through aggressive treatment.

Best for fastest visible results: Profhilo — Profhilo typically shows hydration and glow improvements within 1 to 2 weeks, while Rejuran results build more gradually over 2 to 3 months.

Can You Do Both Rejuran and Profhilo?

Yes, and many of our patients do. This is one of the most underrated facts about skin boosters. Rejuran and Profhilo work on completely different mechanisms, which means they complement rather than compete with each other.

Here is a typical sequence our doctors might recommend:

Phase 1 (Repair): Start with 3 sessions of Rejuran spaced 4 weeks apart. This rebuilds the skin’s foundation, calms inflammation, and addresses scars or sensitivity.
Phase 2 (Remodel): Follow up with 3 sessions of Profhilo for hydration, firmness, and that visible bounce. The healthier skin from Rejuran responds even better to Profhilo.
Phase 3 (Maintain): Alternate top up sessions every 6 to 9 months depending on your skin’s needs.

That said, stacking treatments needs a doctor’s plan. Timing matters. Doing them too close together can lead to unnecessary downtime or wasted sessions. Our doctors at Five Clinic® will map out the right sequence based on your goals, budget, and how your skin behaves.

Side by Side: Comfort, Downtime, and Cost

Comfort during the treatment

Profhilo is generally more comfortable because of its smooth, flowing texture and the small number of injection points (just 5 per side of the face). Rejuran can feel slightly more uncomfortable due to its thicker consistency and the larger number of injection points needed across the face. Both treatments use numbing cream for 30 minutes beforehand, which significantly reduces discomfort.

Downtime

Both have minimal downtime, but the after effects look slightly different. Rejuran leaves tiny bumps at injection sites for 1 to 2 days. Profhilo may cause mild redness or temporary lumps that settle within 24 to 48 hours. Most patients return to normal activities the same day.

Cost

Both fall within the premium skin booster range in Malaysia, with pricing varying by session count, treatment area, and bundled packages. Rejuran typically requires more sessions (3 to 4) than Profhilo (2), which means the total investment for Rejuran is often slightly higher. The most accurate quote comes from a consultation, where our doctors can recommend the right package for your goals.

Why Choose Five Clinic® for Rejuran or Profhilo in Malaysia

At Five Clinic® Bangsar and Puchong, all treatments are guided by MOH certified doctors using only authentic Rejuran and Profhilo products from authorised distributors. Our consultations are free, and our approach is honest. If your skin would do better with one product, a combination, or neither, we will tell you. We believe the best treatment is the one that actually matches your skin, not the one that sounds the most impressive.

So, Which Should You Choose?

There is no universal winner between Rejuran and Profhilo. They are two excellent treatments designed for two different jobs. Choose Rejuran when your skin needs to heal, repair, or recover. Choose Profhilo when your skin needs hydration, firmness, or that bounce back. And if you are struggling with both kinds of concerns, you may benefit from a combination.

If you are still unsure, our pillar guide on which skin booster is best in Malaysia compares all the popular options side by side. Or, the easier route, come in for a free face to face consultation with our doctors and let your skin guide the decision.

Ready to find your match? Reach out to your nearest Five Clinic® branch.

Rejuran vs Profhilo: Which Skin Booster Is Right for You?

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