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Firmer Skin | Renewed Radiance | Polynucleotide Repair

Firmer Skin | Renewed Radiance | Polynucleotide Repair

Plenhyage Skin Booster in Malaysia: Regenerate Skin from Within at Five Clinic®

Plenhyage skin booster is a next generation polynucleotide treatment that helps your skin repair, hydrate and rejuvenate itself from the inside out. Instead of simply adding volume the way a filler does, Plenhyage works with your body’s own regenerative process to improve skin quality, firmness and radiance over time.

At Five Clinic®, every Plenhyage session is planned and performed by certified aesthetic doctors across our Bangsar and Puchong clinics, so you receive a treatment tailored to your skin rather than a one size fits all approach. If you have been searching for a natural looking way to restore tired, dull or ageing skin, this could be the booster you have been looking for.

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skin booster

What is Plenhyage Skin Booster?

Plenhyage is a polynucleotide skin booster, which means its active ingredient is made from purified DNA fragments, most commonly sourced from salmon. These polynucleotides, often shortened to PN, are highly compatible with human skin and act as a signal that tells your cells to repair and renew themselves. Instead of masking the signs of ageing on the surface, Plenhyage works deeper, encouraging your skin to rebuild its own support structure. This is what sets a regenerative booster apart from a traditional filler. A filler adds volume to a specific area, while Plenhyage improves the overall health, texture and resilience of your skin.

If you are already familiar with regenerative treatments such as Rejuran, you can think of Plenhyage as part of the same family of polynucleotide boosters, each with its own formulation and strengths. For many patients, it becomes a foundation treatment that supports and enhances the results of other procedures.

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How Plenhyage Works

How Plenhyage Works

So how does a course of injections improve your skin? It comes down to what polynucleotides do once they are placed into the deeper layers of your skin.

  1. They attract and hold water, giving an immediate boost in hydration that leaves skin looking plumper and more radiant.
  2. They stimulate fibroblasts, the cells responsible for producing collagen and elastin, the two proteins that keep your skin firm, smooth and bouncy. As collagen and elastin production increases over the following weeks, skin becomes noticeably tighter and more elastic.
  3. Polynucleotides have an antioxidant effect, helping to calm inflammation and protect skin cells from the daily damage caused by sun, pollution and stress.

The result is a gradual, natural looking improvement that builds with each session rather than a sudden, obvious change. Because the treatment works with your own biology, results tend to look like a healthier version of your own skin.

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How Plenhyage Works

Plenhyage XL Strong and XL Medium

Plenhyage is available in more than one formulation so your doctor can match the treatment to your skin and the area being treated. The two most common options are Plenhyage XL Strong and Plenhyage XL Medium. During your consultation, your Five Clinic® doctor will assess your skin and recommend the version, or combination, that best suits your goals.

Aspect Plenhyage XL Strong Plenhyage XL Medium
Best suited for Advanced signs of ageing, skin laxity and loss of elasticity Mildly aged or tired skin needing quality improvement and prevention
Strength Higher concentration formulation, around 2.5% polynucleotides, for deeper regeneration Lighter formulation for gentler, everyday skin renewal
Common areas Face, neck, décolletage and arms Face and general areas needing a refresh

Who Is Suitable For Plenhyage?

Works well for those with:

  • Dull, tired or dehydrated skin that needs a boost of radiance
  • Fine lines, loss of firmness or reduced skin elasticity
  • Concerns in the delicate under eye area, including thin skin and a hollow, tired look
  • A preference for natural, gradual results rather than an obvious change
  • A desire to strengthen overall skin quality before or alongside other treatments
  • Interest in a regenerative option instead of, or in addition to, fillers

Who Should Avoid:

  • Pregnant or breastfeeding women
  • Those with an active skin infection, inflammation or breakout in the treatment area
  • Anyone with a known allergy to the treatment ingredients
  • Those with certain autoimmune conditions or bleeding disorders, unless cleared by a doctor
  • Anyone who is unwell or has a fever on the day of the appointment

Treatment Areas Using Plenhyage

Plenhyage is a versatile booster that addresses several common concerns at once.

Face

Under Eye Area

Neck

Décolletage

Our doctors will assess your skin and recommend the most suitable areas and strength based on your goals.

Plenhyage Compared to Fillers and Other Boosters

One of the most common questions we hear is how Plenhyage compares to dermal fillers and to other boosters. The simplest way to understand it is by what each treatment is designed to do. The table below sets out the key differences so you can see where Plenhyage fits.

Feature Plenhyage Dermal Fillers Rejuran
Main purpose Regenerate and improve overall skin quality Add volume and reshape specific areas Heal and repair skin from within, known for scars
How it works Polynucleotides stimulate repair, collagen and hydration Hyaluronic acid fills and lifts tissue Salmon DNA polynucleotides repair, regenerate and calm skin
Adds volume No, it improves skin quality Yes, this is its main effect No, it repairs rather than plumps
Best for Dull, tired, ageing or thin skin needing renewal Loss of volume in cheeks, lips or chin Acne scars, sensitive, reactive or tired skin
Results build Gradually over weeks, across a course Immediately after treatment Gradually over a course of sessions

If your main goal is to restore lost volume in a specific area, a dermal filler may be more suitable. If you want to improve overall skin quality and stimulate long term repair, a polynucleotide booster is usually the better fit. Many patients at Five Clinic® combine approaches, and our doctors will help you decide during your consultation. You may also want to explore our other skin boosters, such as NCTF skin booster, for a complete picture of the options available to you.

Results, Duration & Expectations with Plenhyage

Plenhyage before & after

Before / After Results

Sessions

A short course, usually a few spaced a couple of weeks apart.

Procedure Time

Around thirty minutes, including numbing time.

Downtime

Minimal, just mild redness for a day or two.

Results

Improved hydration and glow within the first couple of weeks, with firmer, smoother skin developing over one to three months as new collagen forms.

Why Choose Plenhyage at Five Clinic® Malaysia

MOH-Certified Doctors

All treatments are guided and monitored by our licensed aesthetic professionals.

Authentic Plenhyage Products

Every treatment uses genuine Plenhyage sourced through authorised distributors, so you can be confident you are receiving the real product and nothing else.

Personalized Treatments

Every skin is special – we create treatment plans that fit your skin type, concerns, and personal goals.

Trustworthy Partner

Get a natural-looking result & caring aftercare support for your skin journey!

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Certified Aesthetic Doctors You Can Trust

Five Clinic

Dr. Calvin Choo

“Dedicated to natural results through safe and effective treatments.”

  • MBBS (First Class Honours), AIMST University

  • LCP-certified aesthetic doctor (Ministry of Health, Malaysia)

  • Former Clinical Director of a leading aesthetic clinic group

  • Trainer & Key Opinion Leader (KOL) for aesthetic products and devices

  • Special interests: Lasers, Fillers, Skinboosters, Botox, Anti-Aging & Acne treatments

Find Me At Five Clinic® Bangsar

Dr. Bernard Chong

“Passionate about helping patients look and feel their best with confidence.”

  • MBBS, Manipal University (MMMC)

  • LCP-certified aesthetic doctor (Ministry of Health, Malaysia)

  • Malaysian Aesthetic Certification (MAC)

  • Member of the American Academy of Aesthetic Medicine (AAAM)

  • Special interests: Collagen Biostimulators, Nose Threadlift, Skin Injectables, Stem Cell Therapy, Acne & Anti-Aging solutions

Find Me At Five Clinic® Puchong

Dr. Hanson Yap

“Committed to natural beauty through precision, safety, and holistic care.”

  • MD, Melaka Manipal Medical College (MMMC)

  • Medical Aesthetic Certification (MAC)

  • Former Medical Officer, Department of Anaesthesiology (pain management & intensive care)

  • Member, Society for the Advancement of Hormones and Healthy Aging Medicine Malaysia (SAHAMM)

  • Special interests: Collagen Biostimulators, Advanced Skin Injectables, Facial Contouring, Anti-Aging & Hormonal Optimisation

What Our Customers Say

Ready to give your skin the support it deserves?

 Book a consultation with our certified doctors to find out whether Plenhyage skin booster is right for you. Simply reach out on WhatsApp and our friendly team will help you arrange a time at the clinic that suits you best.

Five Clinic® Bangsar
Five Clinic® Puchong

Frequently Asked Questions (FAQ)

The cost of Plenhyage depends on the treatment areas and the number of sessions in your plan. Because every patient is different, we provide a clear, personalised quote during your consultation so there are no surprises. Reach out on WhatsApp and our team will be happy to guide you.

Most patients find Plenhyage very tolerable. We apply a numbing cream before the session and use fine needles for the microinjections, so any discomfort is usually mild and brief.

Downtime is minimal. You may have some redness, slight swelling or small injection points for a day or two, but most people return to their normal routine straight away.

Both Plenhyage and Rejuran are polynucleotide boosters that work by regenerating the skin. They differ in their formulation, concentration and the areas they are best suited to. During your consultation, your doctor will recommend the option that fits your skin and goals best.

A dermal filler adds volume to a specific area, while Plenhyage improves the overall quality, hydration and firmness of your skin by encouraging it to repair itself. The two can also work well together as part of a wider plan.

Many patients notice improved hydration and glow within the first couple of weeks. Firmer, smoother skin develops over one to three months as new collagen forms. Results can be maintained with top up sessions every several months.

Plenhyage works best as a short course of sessions rather than a single treatment. The exact number depends on your skin and your goals, and your doctor will confirm your ideal plan at your consultation.

Plenhyage uses purified, highly biocompatible polynucleotides and is administered only by certified doctors at Five Clinic®. Side effects are usually limited to mild, short lived redness or swelling at the injection sites.

Yes. Plenhyage is often combined with other treatments such as boosters, lasers or fillers as part of a complete skin plan. Your doctor will design a combination that is safe and effective for you.

Say hi to healthier skin. Schedule your first visit now!

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Five Clinic®

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Medically reviewed by Dr. Calvin Choo (LCP-certified)

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